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HIPERTENSIÓN / 2015 / VOL. 20

84

Bibliografía

1. Hermida R, Ayala D, Calvo C. Chronoterapy of Hypertension. Advanced Drug Delivery Reviews 59 (2007) 923 – 939.

2. Hermida R, Smolensky M, et al Curr Opin Nephrol Hypertens 2004; 13:501-505.

3. Hermida R, Ayala D, Calvo C, et al Chronobiology and Chronoterapy. Hypertension 2004; 21(5);256-270.

4. Hermida R, Ayala D, and Calvo C. Administration–time–dependent effects of antihypertensive treatment on the circadian pattern of blood pressure. Current

Opinion in Nephrology and Hypertension 2005, 14: 453 – 459.

5. Smolenski M, Hermida R, Ayala D, et al Administration-time- dependent effect of blood pressure-lowering medications: basis for the chronoterapy of

hypertension. Blood Pressure Monitoring 2010, 15:173-180.

6. Lafuente M, Cabal A, Lopez F, et al Administracion temporalizada de fármacos antihipertensivos. Primeros pasos desde una consulta rural de Atención

Primaria. Hipertensión (Madr.) 2008; 25(4):147-150.

7. Dolan E, Stanton A, Thijs L, et al. Superiority of Ambulatory Over Clinic Blood Pressure. Measurement in Predicting Mortality. The Dublin Outcome Study

Hypertension. 2005;46:156-161.

8. Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension

1994; 24: 793 – 801.

9. Ohkubo T, Hozawa A, Yamaguchi J, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood

pressure: The Ohasama study. J Hypertens 2002; 20: 2183 – 2189.

10. De la Sierra A, Redon J, Banegas J, et al. Prevalence Circadian Blood Pressure Patterns in Hypertensive Patients. Hypertension 2009; 53: 466 – 472.

11. Hermida C, Ayala E, Fernandez J, et al. Circadian Rhytms in Blood Pressure Regulation and optimization of Hypertension Treatment With ACE Inhibitor and

ARB Medications. American Journal of Hypertension. 2011April vol.24number 4:389-391.

12. Ohmori M, Fujimura A, et al. ACE Inhibitors and Chronotherapy. Clin Exp Hypertens 2005; 27:179-185.

13. Hermida C, Ayala D, Smolensky M, et al. Chronoterapeutics of Convencional Blood Pressure-Lowering Medications: Simple, Low-Cost Means of Improving

Management and Treatment outcomes of Hypertension Related Disordes. Curr Hypertens Rep 2014;16:412.

14. Potúcek P, Klimas J, et al. Chronoterapy of Hypertension With Combination Treatment. Pharmazie 2013 Dec;68(12)921-925.

15. Calvo C, Lopez T, Hermida A, et al Combinación de Telmisartan y Amlodipino. Cronoterapia en pacientes ancianos. Rev Esp. Cardiol. 2012;65 supl. 3:219.

16. Mens Y, Zhang Z, Liang X, et al Effect of Combination Therapy With Amlodipine and Fosinopril Administered at Different Time on Blood Pressure and Circadian

Blood Pressure Pattern in Patient With Essencial Hypertension. Acta Cardiol 2010;65(3)309-314.

17. Hermida C, Ayala D, Fontao M, et al. Chronoterapy With Valsartan/ Amlodipine Fixed Combination: Improved Blood Pressure Control of Essencial Hypertensio

With Bedtime Dosing. Chronobiology International, 2010, 27(6):1287-1303.

18. Stranges PM, Drew AM, Rafferty P, et al. Treatment of Hypertension With Chronoterapy: Is it Time of Drug Administration? Ann Pharmacother. 2015

mar;49(3):323-334.

• La Asociación Americana de Diabetes (ADA), considerando la relevancia de la cronoterapia

en la HTA, recomienda a los pacientes con diabetes, ingerir uno o más medicamentos

antihipertensivos al acostarse.

• En España, cuando se usan varios antihipertensivos, recomiendan administrar al menos

uno en la noche (SEH – LEHA).

• En la HTA refractaria, en que se usan varias combinaciones de antihipertensivos, se

recomienda que al menos uno o más medicamentos se administren al acostarse, de

preferencia aquellos que bloquean el SRAA.

• Siempre hay que INDIVIDUALIZAR el tratamiento según las características del paciente

que vamos a tratar.

Conclusiones Finales