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HIPERTENSIÓN / 2014 / VOL. 19

16

La Guía termina con un interesante comentario sobre temas relevantes que todavía están en

discusión y que deben ser analizados a través de futuras investigaciones. Se mencionan brechas

a dilucidar a través de 13 preguntas, lo cual sólo demuestra que en HTA no está todo escrito.

Bibliografía

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James P, Oparil S, Carter B et al. 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults. Report from the panel members

appointed to the Eight Joint National Committe (JNC 8). JAMA. 2014;311(5):507-520

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Zanchetti A, Grassi G, Mancia G. When should antihypertensive drug treatment be initiated and to what levels should systolic blood pressure be lowered?

A critical reappraisal. J Hypertens 2009; 27: 923-934

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Schier RW, Estacio RO, Esler A et al. Effects of agressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and

stroke. Kidney Int 2002; 61:1086-1097.

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The ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010;362:1575-1585.

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substudy. Lancet 2000; 355: 253-259

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Advance Collaborative Group. Effects of a fixed combination of perindropil and indapamide on macrovascular and microvascular outcomes in patients with

type 2 diabetes mellitus ( the ADVENCE trial ): a randomised controlled trial. Lancet 2007; 370: 829-840

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Estacio RO, Jeffers BW, Gifford N et al. Effect of blood pressure control on diabetic microvacular complications in patients with hypertension and type 2

diabetes. Diabetes Care 2000; 23 (Suppl. 2): B54-B64

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Hansson L, Zanchetti A, Carruthers SG, et al. Effects of intensive blood- pressure lowering and low-dose aspirin in patients with hypertension: principal results

of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998; 351:1755-1762

10.

UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes; UKPDS

38. Br Med J 1998:317:703-713

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JATOS Study Group. Principal results of the Japanese Trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS). Hypertens Res

2008; 31: 2115-2127

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Zhang Y, Zhang X, Liu L, et al. Is a systolic blood pressure target < 140 mmHg indicated in all hypertensives? Subgroup analysis of findings from the randomized

FEVER trial. Eur Heart J 2011; 32:1500-1508

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Blood Pressure Lowering Treatment Trialists ´Collaboration. Effects of different regimens to lower blood pressure on major cardiovascular events in older and

younger adults: meta-analysis of randomised trials. BMJ 2008; 336: 1121-1123

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Wright J, Bakris G, Greene T et al. Effect of blood pressure lowering and hypertensive drug class on progression of hypertensive kidney disease: results from

de AASK Trial. JAMA 2002; 288:2421-2431

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Upadhyay A, Earley A, Haynes SM et al. Systematic review: blood pressure target in chronic kidney disease and proteinuria as an effect modifier. Ann Intern

Med 2011; 154:541-548

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Dahlof B, Devereux R, Kjeldsen et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE):

a randomised trial against atenolol. Lancet 2002; 359:995-1003

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Law M , Morris J, Wald N. Use of blood-pressure-lowering drugs in the prevention of cardiovascular disease: meta analysis of 147 randomised trials in the

context of expectations from prospective epidemiological studies. BMJ 2009 338, b1665.

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Willian B, Lacy P, Thom S, et al. Differential impact of blood pressure lowering drugs on central aortic pressure and clinical outcomes: principal results of the

Conduit Artery Function Evaluation (CAFE) study. Circulation 2006;113: 1213-125.