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Caracterización clínica, serológica y patrón
radiológico de una cohorte unicéntrica de pacientes
con enfermedad pulmonar difusa
José Miguel Chahuán S.*, María Jesús Fuenzalida L.**, Pabla Cataldo V.*,
Macarena Lagos C.**, Isabel De La Fuente M.***, Gonzalo Pereira R.****,
José Pizarro P.**** y Matías Florenzano V.*****
Clinical, serological and radiological pattern characterization of a monocentric
cohort of patients with diffuse lung disease
Diffuse Lung Disease (DLD) is an important cause of morbidity and mortality, however in Chile
we are lacking of epidemiological data on this condition. Our aim is communicate the first report
of a prospective registry of DLD patients treated at bronchopulmonary unit of DIPRECA hospital.
Methods
: Cross-sectional study in patients referred to our bronchopulmonary unit under suspicion of
DLD. Diagnosis was confirmed by chest computed tomography and informed consent was approved
by patients. Data regarding clinical, serological, pulmonary function tests and echocardiography were
collected from 2014 up to date.
Results:
30 patients were analysed, their median of age was 76.5 years-
old (Interquartile Range 68-80), 56.7% were women, median duration of disease: 4 years (IQR 1-10.6)
and 43% has smoking history. Most frequent signs and symptoms were crackles (97%), dyspnoea (90%)
and cough (57%). Comorbidities: 3% had asthma, 3% chronic obstructive pulmonary disease and 6.7%
connective tissue diseases. Radiological findings: 20% had DLD with usual interstitial pneumonia
pattern (UIP), 23% DLD possible UIP, 30% DLD inconsistent with UIP, 14% chronic hypersensitivity
pneumonitis and 13% nonspecific interstitial pneumonia. Serology: 18% had positive rheumatoid factor
of which only one case had rheumatoid arthritis, 67% had positive antinuclear antibodies (ANA), 17%
ANCA positive of which only one case of clinical vasculitis. Spirometry was mainly normal (52%) or
restrictive (45%). Echocardiography showed pulmonary hypertension mainly mild in 52% of patients.
No significant association was found between titles of ANA ≥ 1/320 and gender, smoking or radiolo-
gical pattern.
Conclusions:
Our demographic and radiological findings are similar to those reported
in literature; however, the highlights in our cohort are the increased frequency of female gender and
positive ANA without history or clinical manifestation of connective tissue diseases.
Key words:
Idiopathic pulmonary fibrosis, tomography X-Ray computed, female, antibodies, an-
tinuclear, cross-sectional studies.
Resumen
La enfermedad pulmonar difusa (EPD) es causa importante de morbimortalidad; a pesar de
esto no tenemos datos epidemiológicos en Chile. Nuestro objetivo es comunicar el primer reporte del
registro prospectivo de pacientes con EPD atendidos en la unidad de broncopulmonar del hospital DI-
PRECA.
Métodos
: Estudio de corte transversal en pacientes derivados al policlínico broncopulmonar
del hospital DIPRECA por sospecha de EPD. En caso de confirmación diagnóstica por tomografía
computada de tórax y consentimiento informado aprobado por los pacientes, se compilaron datos clí-
* Residente Medicina Interna, Universidad de Valparaíso.
** Residente Medicina Interna, Universidad Diego Portales.
*** Unidad de Broncopulmonar Hospital DIPRECA.
**** Unidad de Radiología Hospital DIPRECA (Dirección de Previsión de Carabineros de Chile). Las Condes, RM.
*****Instituto Nacional del Tórax, Providencia, Santiago, Chile.
Rev Chil Enferm Respir 2017; 33: 31-36
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