

C o n t e n i d o d i s p o n i b l e e n h t t p : / / www. n e umo l o g i a - p e d i a t r i c a . cl
14
Neumol Pediatr 2018; 13 (1): 11 - 14
Neumopatía por aspiración (Sindrome aspirativo)
de ellos de manera aislada cumple con una sensibilidad y una
especificidad suficiente para ser concluyentes en el diagnóstico,
por lo que tenemos que apoyarnos en al menos dos estudios.
Cuando se instaura el diagnóstico se tiene que actuar de manera
oportuna en el tratamiento médico o quirúrgico por el riesgo de
complicaciones graves.
El autor declara no presenter conflicto de interés.
REFERENCIAS
1. Bauer ML, Lyrene RK. Chronic aspiration in children: Evaluation
of the lipid-laden machropage index. Pediatr Pulmonol.
1999;28:94-100.
2. Kirsch CM, Sasnders A. Aspiration pneumonia, medical
management. Otorinolaryngol Clin North Am 1988;21:677-
689.
3. Colombo JL, Hallberg TK. Recurrent aspiration in children: Lipid
ladden alveolar macrophage quantitation. Pediatr Pulmonol
1987;3:86-89.
4. Furuya ME, Moreno-Cordova V, Ramírez-Figueroa JL, Vargas
MH, Ramón-García G, Ramírez-San Juan DH. Cutoff value of
lipid-ladden alveolar macrophages for diagnosing aspiration
in infants and children. Pediatr Pulmonol 2007;42:452-457.
5. Primer Consenso Nacional para el Estudio del Niño con
Neumopatía Crónica. Sociedad Mexicana de Neumología y
Cirugía de Tórax. Acta Pediatr Mex 2004;25(3):193-200.
6. Ramirez J, Mata N, Cervantes R, Zarate F, Zaragoza G. pH-
metría y serie esofago gastro duodenal en niños con reflujo
gastroesofagico. Bol Med Hosp Infant Mex 2000;57:200-
204.
7. Mikita C, Callahan C. Aspiration syndromes. Medicine
Specialities. Pediatric Pulmonology. Available at URLA http//
www.emedicine.com/ped/topic26222.htm.Accessed on
August 2006
8. Corwin RW, Irwin RS. The lipid laden alveolar macrophages as
a marker of aspiration in parenchymal lung disease. Am Rev
Respir Dis 1985;132:576-581.
9. Ahrens P, Noll C, Kitz R, Willigens P, Zielen S, Hofmann D.
Lipid-laden macrophages (LLAM): a useful marker of silent
aspìration in children. Pediatr Pulmonol 1999;28:83-88.
10. Colombo JL, Hallberg TK. Recurrent aspiration in children:
lipid- laden alveolar macrophage quantitation. Pediatr
Pulmonol 1987; 3:86–89.
11. Gibeon D, Zhu J, Sogbesan A, Banya W, Rossios C, Saito J,
Rocha JP, Hull JH, Menzies-Gow AN Bhavsar PK, Chung KF.
Lipid-laden bronchoalveolar macrophages in asthma and
chronic cough. Respir Med 2014;108:71-77.
12. Hadda V, Khilnani GC. Lipoid pneumonia: an overview. Expert
Rev Respir Med 2010 ;4(6):799-807.
13. Adams R, Ruffin R, Campbell D. The value of the lipid-
laden macrophage index in the assessment of aspiration
pneumonia. Aust N Z J Med 1997;27(5):550-3.
14. Parameswaran K, Anvari M, Efthimiadis A, Kamada D,
Hargreave FE, Allen CJ. Lipid-laden macrophages in induced
sputum are a marker of oropharyngeal reflux and possible
gastric aspiration. Eur Respir J 2000 Dec;16(6):1119-22.
15. Wright JR, Youmans DC. Degradation of surfactant lipids and
surfactant protein A by alveolar macrophages in vitro. Am
J Physiol 1995 May;268(5 Pt 1):L772-80.16. Reasor MJ,
Hastings KL, Ulrich RG. Drug-induced phospholipidosis:
issues and future directions. Expert Opin Drug Saf 2006
;5(4):567-83.
17. Jacobson W, Stewart S, Gresham GA, Goddard MJ. Effect of
amiodarone on the lung shown by polarized light microscopy.
Arch Pathol Lab Med 1997;121(12):1269-71.
18. Colombo J MD, Sammut PH MD. Aspiration (foreing body, food,
chemical). In: Pediatric Pulmonology. American Academy
of Pediatrics Section on Pediatric Pulmonology. 2011.
ISBN:978-1-58110-492-9.
19. Starosta V, Kitz R, Hartl D, Marcos V, Reinhardt D, Griese M.
Bronchial pepsin, bile acids, oxidation, and inflammation
in children with gastroesophageal disease. Chest.
2007;132;1557-1564.