Asociaciones entre factores de riesgo modificables y cambios en el estado glucémico entre individuos con prediabetes Nabila S, Kim JE, Choi J, Park J, Shin A, Lee SA, et al. Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes Diabetes Care 2023 Jan 10;[EPub Ahead of Print], El objetivo fue examinar las asociaciones entre los factores de riesgo modificables y los cambios en el estado glucémico en personas con prediabetes. En el presente estudio se incluyeron un total de 10,358 personas con prediabetes definida por sus niveles de glucosa en sangre en ayunas y HbA1c del estudio Health Examinees-Gem. Se examinaron los factores modificables, incluidos el IMC, la obesidad abdominal, el tabaquismo, la actividad física, el consumo de alcohol, la calidad de la dieta, la hipertensión y la dislipidemia, para determinar sus asociaciones con los cambios en el estado glucémico durante el seguimiento. Además, se calcularon las puntuaciones de los factores modificables y también se analizó su asociación con los cambios en el estado glucémico. La mediana del tiempo de seguimiento para este estudio fue de 4 años (rango, 1-7 años). IMC ≥25 kg/m2 (odds ratio ajustado [OR] 0.71 [IC 95% 0.63-0.79]), obesidad abdominal (OR 0.76 [IC 95% 0.68-0.86]), consumo excesivo de alcohol (OR 0.74 [IC 95% 0.60- 0.91]), la hipertensión (OR 0.71 [IC 95% 0.64-0.79]) y la dislipidemia (OR 0,78 [IC 95% 0,70-0,85]) se asociaron con una menor posibilidad de reversión de la normoglucemia. IMC ≥25 kg/m2 (OR 1.58 [IC 95% 1.29-1.94]), obesidad abdominal (OR 1.31 [IC 95% 1.11-1.55]), tabaquismo actual (OR 1.43 [IC 95% 1.07-1.91]) y hipertensión (OR 1.26 [IC 95% 1.07-1.49]) se asociaron con una mayor probabilidad de progresión de la diabetes tipo 2. Tener factores modificables más favorables también se asoció con la reversión de la normoglucemia (OR 1.46 [IC 95% 1.30-1.64]) y la progresión de la diabetes tipo 2 (OR 0,62 [IC 95% 0,49-0,77]). En conclusión, los factores modificables más favorables se relacionaron con una mayor probabilidad de volver a la normoglucemia y una menor probabilidad de progresión a diabetes tipo 2. Context and Objective Design and Methods Study Background Study Objective Study Population Modifiable Factors Prediabetes is a critical condition that is likely to progress to type 2 diabetes, but also is potentially reversible. Thus, it is important to know the determinants that may be bey to the change in prediabetes glycemic status. However, only a few population-based studies have included modifiable factors to determine their association with changes in glycerni status from prediabetes. Acknowledgement: This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2018R1A2A3075397 and NRF-2022R1A2B5B01DD2471) and Korea Centers for Disease Control and Prevention (2004-18 E71004-00, 2005-E71011-00, 2005-E71009-00, 2006-E71001-00, 2006-E71004-00, 2006-E71010-00, 2006-19 E71003-00, 2007-E71004-00, 2007-E71006-00, 2008-E71006-00, 2008-E71008-00, 2009-E71009-00, 2010-20 E71006-00, 2011-E71006-00, 2012-E71001-00, 2013-E71009-00, 2018-P7106-00, and 2021-E0608-00). Multinomial logistic regression was performed to obtain the odds ratio for normoglycemia reversion and progression to type 2 diabetes by setting the prediabetes persistence as the reference group. Source population: HEXA-G participants with follow-up n=64, 485) The purpose of the study was to examine the role of modifiable factors in reversion to normoglycemia, we well as progression to type 2 diabetes among people with prediabetes defined by their FPG and HbA1c levels. The outcomes of the study consisted of three Modifiable factors score was derived by summing all the total scores of dichotomizing these variables. Normoglycemia reversion Prediabetes persistence Diabetes progression Included participants: Individuals with prediabetes (n=10,358) *categorized based on FPG and HbA1c levels, as well as history of diabetes at follow-up by referring to ADA criteria *defined by FPG and HbA1c levels at baseline and selected by referring to ADA criteria Physical Activity Body Mass Index Abdominal Obesity Smoking Status Alcohol Consuption Statistical Analysis Diet Quality Hypertension Dyslipidemia More favorable modifiable factors were related to a higher probability of returning to normoglycemia and a lower probability of progression to type 2 diabetes Conclusion OR 0.71 [0.63–0.79] OR 0.76 [0.68–0.86] OR 0.74 [0.60–0.91] OR 0.76 [0.68–0.86] OR 0.78 [0.70–0.85] OR 1.58 [1.29–1.94] OR 1.31 [1.11–1.55] OR 1.43 [1.07–1.91] OR 1.26 [1.07–1.49] BMI ≥25 kg/m2 Abdominal obesity Current smoking Heavy drinking Hypertension Dyslipidemia Modifiable factors score Unfavorable group (score 0-4) Intermediate group (score 5) Favorable group (score 6-7) 0.00 Lower probability of normoglycemia reversion 2.00 Higher probability of diabetes progression 1.00 1.00 1.00 1.00 0.00 Lower probability of diabetes progression 2.00 Higher probability of normoglycemia reversion Reference OR 0.81 [0.67–0.89] OR 0.62 [0.49–0.77] Reference OR 1.19 [1.06–1.33] OR 1.46 [1.30–1.64] 67 ATEROMA - Resúmenes
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